Microglia, the major population of brain resident macrophages, differentiate from yolk sac progenitors in the embryo and plays multiple non-immune roles in brain organization throughout development and life. Various microglia subtypes have been described by transcriptomic, proteomic, metabolic, morphology, intracellular complexity, time of residency and ontogeny, both in development and in disease settings. Such macrophage heterogeneity increases with aging or neurodegeneration with monocyte infiltration and differentiation into monocyte-derived macrophages (MDM). We aim to understand key processes through which macrophages contribute to neurodevelopment and how these processes can be reuse or disturb during inflammation and neurodegenerative diseases.
Former team members: Reyhane Labsy, Wissal Fedda.
Collaborators: Morgane Thion, Sonia Garel, Guillaume Dorothé, Marc Dhenain
We are thankful to Fondation Recherche Alzheimer for their support.
Related manuscript:
Joly P, Labsy R, Silvin A. Aging and neurodegeneration: When systemic dysregulations affect brain macrophage heterogeneity. Journal of Immunology. 2025. In press.
Silvin A, Uderhardt S, Piot C, Da Mesquita S, Yang K, Geirsdottir L, et al. Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration. Immunity. 2022 Aug 9;55(8):1448-1465.e6.
