Florent GINHOUX

I am an immunologist with a background in biochemistry and immunology. I graduated in Biochemistry from the University Pierre et Marie CURIE (UPMC), Paris VI, and obtained a Master's degree in Immunology from the Pasteur Institute in 2000. I earned my PhD in 2004 from UPMC, Paris VI. After completing my doctoral studies, I joined the Laboratory of Miriam Merad at the Mount Sinai School of Medicine (MSSM) in New York as a postdoctoral fellow. In 2007, I became an Instructor in the Department of Gene and Cell Medicine at MSSM and a faculty member of the Immunology Institute. I was promoted to Assistant Professor in the Department of Gene and Cell Medicine at MSSM in 2008.  

In May 2009, I joined the Singapore Immunology Network (SIgN), A*STAR, as a Junior Principal Investigator, and I was promoted to Senior Principal Investigator in 2014. Since July 2021, I have been leading a laboratory at Gustave Roussy in Villejuif, France, where my research focuses on myeloid cells in cancer.Throughout my career, I have been honored with several prestigious awards, including the EMBO Young Investigator award in 2013, which recognizes young, promising researchers under forty who have established their first laboratories in Europe and EMBO cooperation partner countries.  

In 2014, I received the European Macrophage and Dendritic Cell Society Junior Prize. I have also been a Web of Science Highly Cited Researcher since 2016, and in 2022, I was elected a full EMBO Member.

My laboratory aims to understand the ontogeny of dendritic cells, monocytes, and macrophages, as well as their differentiation pathways and how these processes influence their immune functions. Macrophages, monocytes, and dendritic cells play essential roles in tissue homeostasis and immunity, but they also contribute to a broad range of pathologies, making them attractive therapeutic targets. My research focuses on uncovering the origins and mechanisms that govern the homeostasis, activation, and heterogeneity of these cells, which is crucial for developing intervention strategies to manipulate their functions in disease.