Immune System, Precision Oncology, and Future Thyroid Research: Highlights From Gustave Roussy and the Florent Ginhoux Lab
This quarter brought important advances to Gustave Roussy, illustrating the strength of our institute in immunology, precision oncology, and therapeutic development. Several of these breakthroughs involve leaders closely connected to our laboratory.
The Immune System: A Central Regulator of Human Physiology
Work led by Prof. Florent Ginhoux
In a recent Science article, Prof. Florent Ginhoux and collaborators (Harvard University, Mount Sinai Hospital) show that the immune system is far more than a defense mechanism. Immune cells circulate through every organ, interacting with neurons, muscle cells, and endocrine networks. They influence memory, cardiac metabolism, tissue regeneration, bone and muscle repair, and even pregnancy and lactation.
This work positions the immune system as a true conductor of the body’s physiological balance—an idea central to our lab’s research.
Read the article https://www.science.org/doi/10.1126/science.adx4380
AI to Personalise Breast Cancer Treatment
Coordinated by Prof. Fabrice André
A study published in the Journal of Clinical Oncology, led by Prof. Fabrice André, demonstrates the potential of an AI-based test to refine treatment decisions in HR-positive, HER2-negative breast cancer. The test identified that 20% of women labelled “high risk” are actually at low risk of relapse, with 95% showing no recurrence after nine years.
This approach could reduce unnecessary treatment and support more personalised care.
Read the article https://ascopubs.org/doi/10.1200/JCO-25-00742
New Hope for Rare Thymic Cancers
The PECATI phase II trial reports promising results using a lenvatinib–pembrolizumab combination for advanced thymic cancers: 88.4% of patients showed no progression after five months, offering a potential new option for those without alternatives.
Read the article https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(25)00300-6/abstract?rss=yes
What’s Next for the Florent Ginhoux Lab: Thyroid Immunobiology
Our team is also investigating thyroid tumors to identify potential biomarkers and uncover new therapeutic targets
